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Laboratory of biological chemistry


Hello, everybody. Welcome to the Laboratory of biological chemistry!

My laboratory is interested in deciphering the role of protein phosphatases in various cellular paradigms, as phosphatases play key roles in processes such as the development of cancer, axonal pathfinding, and bacterial pathogenesis.

Cyworld Club of Lab. of Biological Chemistry in Konkuk Univeristy

실험실사진 Among phosphatases, we are mainly focusing on Lipid Phosphatases and CTD Phosphatases. My laboratory has used following methodology to investigate the cellular function and biological roles of Lipid Phosphatases and CTD Phosphatases. Among CTD Phosphatasee, we are focusing on a CTD-specific phosphatase belonging to the family of Fcp1-like enzymes known as Scp1 was characterized and shown to act as an evolutionarily conserved transcriptional corepressor for inhibiting neuronal gene transcription in nonneuronal cells.
실험실사진Among Lipid Phosphatase, we are focusing on Ciona intestinalis voltage sensor-containing phosphatase (Ci-VSP), consisting of an ion channel-like transmembrane domain followed by a phosphatase domain which shares sequence identity to the phosphatase and tensin homolog deleted on chromosome 10q23 (PTEN). PTEN is a well characterized PI phosphatase that dephosphorylates the phosphate on the 3 position of PI(3,4,5)P3, resulting in generation of PI(4,5)P2. Ci-VSP shares overlapping substrate specificity with PTEN in that it was also shown to dephosphorylate PI(3,4,5)P3.
Research Area
  • Lipid Phosphatase
  • CTD Phosphatase
  • Lipidomics/Proteomics
  • Systems Biology
  • Cancer and Stem Cell
  • Inflammation